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Food For Thought

Food for Thought MicrobiomeHuman Microbiome Research

"human microbiome"

"human microbiome": Latest results from PubMed

Updating the Discontinuity Theory to the Extended Immunity: The Symmunobiome Concept

The immune system (IS) is commonly understood as a system composed of specific cells and tissues that have evolved to...
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Similarity of drug targets to human microbiome metaproteome promotes pharmacological promiscuity

Similarity between candidate drug targets and human proteins is commonly assessed to minimize the occurrence of side ...
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Zero inflated high dimensional compositional data with DeepInsight

Through the Human Microbiome Project, research on human-associated microbiomes has been conducted in various fields. ...
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Pneumocystis jirovecii is a potential pivotal ecological driver contributing to shifts in microbial equilibrium during the early-life lower airway microbiome assembly

Early life gut microbiota is being increasingly recognized as a major contributor to short and/or long-term human hea...
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Insights into Autophagy in Microbiome Therapeutic Approaches for Drug-Resistant Tuberculosis

Tuberculosis, primarily caused by Mycobacterium tuberculosis, is an airborne lung disease and continues to pose a sig...
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Lactobacillus acidophilus potentiates oncolytic virotherapy through modulating gut microbiota homeostasis in hepatocellular carcinoma

Oncolytic viruses (OVs) hold promise for cancer treatment. However, the antitumor efficacy is limited. Microbiota pla...
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Patients with post-COVID-19 condition show minor blood transcriptomic changes, with altered erythrocyte gene expression in a male subgroup

CONCLUSIONS: Persistent symptoms in PCC are multifactorial and not directly linked to peripheral blood cell gene expr...
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MetaDAVis: An R shiny application for metagenomic data analysis and visualization

The human microbiome exerts tremendous influence on maintaining a balance between human health and disease. High-thro...
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Therapeutic potential of microbiome modulation in reproductive cancers

The human microbiome, a complex ecosystem of microbial communities, plays a crucial role in physiological processes, ...
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Modulation of Host Immunity by Microbiome-Derived Indole-3-Propionic Acid and Other Bacterial Metabolites

In recent years, we have witnessed a rapidly growing interest in the intricate communications between intestinal micr...
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Embracing the unknown: Proteomic insights into the human microbiome

Protein-level investigations into the human microbiome provide insights into active microbial functions. Recently, Va...
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Unraveling the potential of bioengineered microbiome-based strategies to enhance cancer immunotherapy

The human microbiome plays a pivotal role in the field of cancer immunotherapy. The microbial communities that inhabi...
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Large-scale biosynthetic analysis of human microbiomes reveals diverse protective ribosomal peptides

The human microbiome produces diverse metabolites that influence host health, yet the chemical landscape of ribosomal...
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Modeling microbiome-trait associations with taxonomy-adaptive neural networks

The human microbiome, a complex ecosystem of microorganisms inhabiting the body, plays a critical role in human healt...
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Gut virome and its implications in the pathogenesis and therapeutics of inflammatory bowel disease

Inflammatory bowel disease (IBD) refers to chronic, recurrent inflammatory intestinal disorders, primarily including ...
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Unlocking the Interactions Between the Whole-Body Microbiome and HPV Infection: A Literature Review

The human microbiome plays a vital role in maintaining human homeostasis, acting as a key regulator of host immunity ...
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Temporal dynamics and metagenomics of phosphorothioate epigenomes in the human gut microbiome

BACKGROUND: Epigenetic regulation of gene expression and host defense is well established in microbial communities, w...
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Genomic and proteomic characterization of four novel Schitoviridae family phages targeting uropathogenic Escherichia coli strain

CONCLUSION: The overall findings suggest that these bacteriophages are potential candidates for phage therapy in trea...
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The Oral Microbiome and Us

Oral and systemic human health depend on the symbiotic relationship between the human host and its microbiome. As the...
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Food for Thought Paleo Diet 2Paleo Diet Research

paleo diet

paleo diet: Latest results from PubMed

Assessing Breastfeeding Attitudes and Self-Efficacy Among Health care Personnel and Women With Multiple Sclerosis: Two Cross-Sectional Surveys

INTRODUCTION: This study aimed to describe breastfeeding attitudes among health care personnel, as well as breastfeed...
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Effects of a Multimodal Lifestyle Intervention on Cardiometabolic Markers in People with Progressive Multiple Sclerosis: A Secondary Analysis of a Pilot Study

Background: Cardiometabolic comorbidities are common in multiple sclerosis (MS), and lifestyle interventions are effe...
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High-resolution isotope dietary analysis of Mesolithic and Neolithic humans from Franchthi Cave, Greece

Franchthi Cave, in the Greek Peloponnese, is a well-known Paleolithic, Mesolithic and Neolithic site, with several hu...
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Obesity and Weight Loss Diets in Inflammatory Bowel Disease Patients: What Physicians Should Know

Nutritional approach has been intensely investigated in inflammatory bowel disease (IBD) patients, but, despite many ...
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Harnessing tumor metabolism during cancer treatment: A narrative review of emerging dietary approaches

Cancer is currently one of the biggest public health challenges worldwide, ranking as the second leading cause of dea...
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Efficacy of a High-Protein Diet to Lower Glycemic Levels in Type 2 Diabetes Mellitus: A Systematic Review

Diabetes is a metabolic disease with a high worldwide prevalence and an important factor in mortality and disability ...
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Trigger Warning: How Modern Diet, Lifestyle, and Environment Pull the Trigger on Autosomal Dominant Polycystic Kidney Disease Progression

Understanding chronic kidney disease (CKD) through the lens of evolutionary biology highlights the mismatch between o...
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ALSUntangled #76: Wahls protocol

The Wahls diet is a modified Paleolithic diet that emphasizes dark green leafy vegetables, colorful fruits, high-qual...
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Dietary Recommendations for Glioma: A Mini-Review

PURPOSE OF REVIEW: Glioma is the most common type of brain cancer, associated with a high mortality rate. Diet is one...
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Effects of a Paleolithic diet compared to a diabetes diet on leptin binding inhibition in secondary analysis of a randomised cross-over study

CONCLUSIONS: We found no leptin binding inhibition after the Paleolithic or diabetes diet, possibly due to its abolis...
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Nutritional Management of Hashimoto's Thyroiditis: A Case Report

CONCLUSION: The Paleolithic diet may be used as a nutritional therapeutic protocol in those with HT with who have com...
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From hunter-gatherers to food producers: New dental insights into the Nile Valley population history (Late Paleolithic-Neolithic)

OBJECTIVES: This study presents biological affinities between the last hunter-fisher-gatherers and first food-produci...
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Insights into medieval rural lives: A paleo-odontological investigation of two central European communities

CONCLUSIONS: Using multiple dental parameters to examine the oral health of premodern individuals can provide useful ...
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The Association Between Hidradenitis Suppurativa and Diet: An Update

Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition characterized by painful inflammatory lesions,...
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Spatial ecology of moose in Sweden: Combined Sr-O-C isotope analyses of bone and antler

The study of spatial (paleo)ecology in mammals is critical to understand how animals adapt to and exploit their envir...
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The association between paleolithic diet pattern scores and psychological disorders in Iranian adults

CONCLUSIONS: Our research indicates that adhering to a Paleolithic diet, either alone or in conjunction with lifestyl...
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Dietary Patterns Associated with Breast Cancer in the Middle East: A Scoping Review

Breast cancer (BC) is the most predominant malignancy in Arab women in the Middle East, and yearly increases in occur...
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Multifunctional dietary interventions, low-grade inflammation and cardiometabolic profile: a scoping review

CONCLUSION: Our findings showed that multifunctional RCT diets have differential role in managing low-grade inflammat...
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[Translated article] Popular Diets and Skin Effects: A Narrative Review

Numerous diets for losing weight, building strength, and managing a range of cardiovascular, neurologic, and skin dis...
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ButterKetogenic Diet Research

"ketogenic diet"

"ketogenic diet": Latest results from PubMed

Deciphering the Controversial Role of TP53 Inducible Glycolysis and Apoptosis Regulator (TIGAR) in Cancer Metabolism as a Potential Therapeutic Strategy

Tumor metabolism has emerged as a critical target in cancer therapy, revolutionizing our understanding of how cancer ...
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Telemedicine for Ketogenic Dietary Treatment in Epilepsy and Inherited Metabolic Diseases: Survey of Health Care Professionals

In refractory epilepsy and inherited metabolic disorders, Ketogenic Dietary Therapies (KDT) are established non-pharm...
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Ketogenic diet improves disease activity and cardiovascular risk in psoriatic arthritis: A proof of concept study

CONCLUSIONS: VLCKD significantly improved PsA activity and metabolic health. Patients with a higher BMI and less cont...
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Nutritional Approaches in Autism Spectrum Disorder: A Scoping Review

PURPOSE OF REVIEW: This review was conducted to discuss the etiology of autism in the light of current information, t...
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Targeting Cytokine Dysregulation in Psoriasis: The Role of Dietary Interventions in Modulating the Immune Response

Psoriasis is a chronic immune-mediated skin disease characterized by cytokine dysregulation. Pro-inflammatory mediato...
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Investigating the Therapeutic Potential of the Ketogenic Diet in Modulating Neurodegenerative Pathophysiology: An Interdisciplinary Approach

The ketogenic diet (KD) is a dietary intervention comprising a high-fat, low-carbohydrate, and moderate-protein intak...
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Ketogenic Diet in Steatotic Liver Disease: A Metabolic Approach to Hepatic Health

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major cause of chronic liver dysfunction worldw...
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The Association Between Lifestyle Interventions and Trimethylamine N-Oxide: A Systematic-Narrative Hybrid Literature Review

CONCLUSIONS: The relationship between dietary interventions and TMAO concentration remains controversial. While certa...
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Clinical analysis of 7 cases of cryptogenic new-onset refractory status epilepticus

There are relatively few studies related to new-onset refractory status epilepticus (NORSE), in which patients with c...
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Advancing Obesity Management: the Very Low-Energy Ketogenic therapy (VLEKT) as an Evolution of the "Traditional" Ketogenic Diet

PURPOSE OF REVIEW: This narrative review comprehensively analyzes VLEKT as an advanced nutritional strategy for obesi...
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Effects of exercise combined with different dietary interventions on cardiovascular health a systematic review and network meta-analysis

CONCLUSION: CR and CR + EX demonstrated the most positive effects on cardiovascular health indicators. In contrast, 5...
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Epilepsy with myoclonic-atonic seizures: an update on genetic causes, nosological limits, and treatment strategies

Epilepsy with myoclonic-atonic seizures is a childhood-onset epilepsy syndrome characterised by a range of seizure ty...
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Association of node assortativity and internalizing symptoms with ketogenic diet effectiveness in pediatric patients with drug-resistant epilepsy

CONCLUSIONS: Twelve months of KDT can reduce monthly seizure frequency and improve mood/behavioral disturbances in pa...
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Can Omega-3 fatty acid supplementation support the clinical management of drug-resistant epilepsy? A meta-analysis of randomized controlled trials

Approximately 30-40% of individuals with epilepsy develop drug-resistant epilepsy (DRE), a condition associated with ...
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Fasting and Headache

PURPOSE OF REVIEW: This review synthesizes the latest updates in the literature on the connection between fasting and...
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A ketogenic-promoting beverage acutely elevates cardiac function and myocardial blood flow compared to placebo in adults: A cardiac MRI investigation

Increasing evidence suggests cardiac function improves in healthy and failing hearts alongside circulating ketones (1...
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Traumatic Brain Injury and Gut Microbiome: The Role of the Gut-Brain Axis in Neurodegenerative Processes

PURPOSE OF REVIEW: A deeper understanding of the communication network between the gut microbiome and the central ner...
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The cyclic metabolic switching theory of intermittent fasting

Intermittent fasting (IF) and ketogenic diets (KDs) have recently attracted much attention in the scientific literatu...
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Nutrition and Lifestyle Interventions in Managing Dyslipidemia and Cardiometabolic Risk

Dyslipidemia, characterized by abnormal blood lipid levels, is a major public health concern due to its association w...
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AI-Powered Analysis of Weight Loss Reports from Reddit: Unlocking Social Media's Potential in Dietary Assessment

Background/Objectives: The increasing use of social media for sharing health and diet experiences presents new opport...
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Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered liver lipid metabolism on a ketogenic diet

Acetyl-CoA Synthetase Short Chain Family Member-1 (ACSS1) catalyzes the ligation of acetate and coenzyme A to generat...
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Ketogenic Diet Intervention for Obesity Weight-Loss- A Narrative Review, Challenges, and Open Questions

PURPOSE OF REVIEW: The ketogenic diet (KD) has gained clinical attention for its potential benefits in weight loss an...
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Ketogenic diets and β-hydroxybutyrate in the prevention and treatment of diabetic kidney disease: current progress and future perspectives

Diabetic kidney disease (DKD) is the main cause of end-stage renal disease. Ketogenic diets (KD) is a high-fat, low-c...
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Oxidative phosphorylation is a key feature of neonatal monocyte immunometabolism promoting myeloid differentiation after birth

Neonates primarily rely on innate immune defense, yet their inflammatory responses are usually restricted compared to...
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Dietary therapy to halt the progression of diabetes to diabetic kidney disease

Diabetic Kidney Disease (DKD) is a common and serious complication of diabetes, particularly Type 2 Diabetes Mellitus...
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Clinical and genetic characteristics of glucose transporter 1 deficiency syndrome in a large cohort of Chinese patients

CONCLUSIONS: The clinical manifestations of Glut1DS primarily include seizures, movement disorders, and developmental...
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The role of dietary factors in cognitive decline

The increasing morbidity and mortality of dementia places a significant burden on society in economic, social and hea...
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Keto therapy-unveiling the potential of ketogenic diet in psychiatric care: A scoping review

CONCLUSIONS: Implementing a KD in patients with mental disorders seems to be a feasible and well-tolerated approach, ...
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Episodic Migraine in the Pediatric Population: Behavioral Therapies and other Non-Pharmacological Treatment Options

PURPOSE OF REVIEW: The purpose of this review is to present current evidence on the multifaceted approach required fo...
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Exploring the effect of valproic acid levels on patients with epilepsy treated with ketogenic diet: An observational study

Ketogenic diet (KD) therapy is an effective treatment for children with refractory epilepsy. Concurrent treatment wit...
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Impact of diet on chronic kidney disease evolution

Chronic kidney disease (CKD) is becoming increasingly common, and adequate nutrition is essential in the management o...
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Effect of sex on neuropsychiatric comorbidities in childhood epilepsy

CONCLUSION: Sex is not yet a well-explored prognostic factor for outcomes following childhood epilepsy, though some s...
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The Influence of Physical Exercise, Ketogenic Diet, and Time-Restricted Eating on De Novo Lipogenesis: A Narrative Review

De novo lipogenesis (DNL) is a metabolic pathway that converts carbohydrates into fatty acids, primarily occurring in...
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Efficacy and Safety of Phase 1 of Very Low Energy Ketogenic Therapy (VLEKT) in Subjects with Obesity and Mild Renal Impairment

Background: Obesity impairs renal function through direct mechanisms, such as proinflammatory adipocytokine productio...
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Navigating the Spectrum of 4 Evidence-Based Nutrition Options for Type 2 Diabetes Management

CONCLUSION: Type 2 diabetes prevention and treatment is crucial in this widespread disease. The first-line treatment ...
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Therapeutic Approach to Epilepsy in Patients with Mitochondrial Diseases

Mitochondrial diseases (MDs) are genetic disorders with diverse phenotypes that affect high-energy-demand organs, not...
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Illnesses associated with ketosis including diabetic ketoacidosis during very low carbohydrate and ketogenic diets

CONCLUSIONS: Very low carbohydrate ketogenic diets are generally safe with low rates of IAK, including DKA, in people...
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Barriers and facilitators to starting and staying on ketogenic diet therapy for children with epilepsy: A scoping review

CONCLUSIONS: Barriers and facilitators for children and young people who are considering starting KDT, or who are cur...
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Obesity-related osteopontin protein and methylation blood levels are differentially modulated by a very low-calorie ketogenic diet or bariatric surgery

CONCLUSIONS: OPN levels were reduced after VLCKD and severely increased after BS. Therefore, it could be a biomarker ...
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Ketogenic diet suppresses colorectal cancer through the gut microbiome long chain fatty acid stearate

Colorectal cancer (CRC) patients have been shown to possess an altered gut microbiome. Diet is a well-established mod...
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Mitigating muscle loss during weight loss: can nutritional ketosis make a difference? A call for more research

Weight loss (WL) has an important role in managing obesity and type 2 diabetes, but preserving lean body mass (LBM) d...
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Very Low Energy Ketogenic Therapy (VLEKT), Not Only a Price Matter: A Comparison Study on Average Costs of VLEKT with Fresh Foods and Replacement Meals

CONCLUSIONS: Although more expensive than a common diet, VLEKT should be seen not only as a dietary method for losing...
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Prophylactic effects of nutrition, dietary strategies, exercise, lifestyle and environment on nonalcoholic fatty liver disease

CONCLUSION: Nutrition, dietary strategies, exercise, lifestyle and environment play an important role in the preventi...
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Subacute Sclerosing Panencephalitis: Impact on Public Health, Current Insights, and Future Perspectives

CONCLUSION: The only prevention for SPPE is through vaccination. Several collaborative efforts have been made with WH...
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Practical experience and challenges in nutritional management of glucose transporter 1 deficiency syndrome: Provider survey results

Ketogenic diets (KDs) are recommended as precision therapy for glucose transporter 1 deficiency syndrome (GLUT-1 DS) ...
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Challenges in Management of Febrile Infection-Related Epilepsy Syndrome: Real-World Experience From a Large Cohort of Pediatric Patients

CONCLUSIONS: The management of FIRES in children is challenging, with limited effectiveness of most currently practic...
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Surgical Treatments, Devices, and Nonmedical Management of Epilepsy

OBJECTIVE: Many patients with epilepsy are unable to achieve optimal seizure control with medical therapy. This artic...
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Early intrathecal dexamethasone (IT-Dexa) associated with faster recovery and good outcome in an adolescent with febrile infection-related epilepsy syndrome (FIRES)

A previously normal adolescent boy presented with a new-onset super refractory status epilepticus of unknown cause af...
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